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DAF-16 is the sole ortholog of the FOXO family of transcription factors in the nematode ''Caenorhabditis elegans''.〔(''daf-16'' at WormBase ) www.wormbase.org〕 DAF-16 is notable for being the primary transcription factor required for the profound lifespan extension observed upon mutation of the insulin-like receptor ''daf-2''. Moreover, the tractability of ''C. elegans'' as a model and interest in teasing out this conserved aging-associated genetic pathway allowed the intricacies of Insulin and Insulin-like growth factor (IGF) Signaling (IIS) to be thoroughly characterized primarily through studies using this model organism. Notable scientists involved in the initial and continued characterization of DAF-16-associated aging pathways: *Cynthia Kenyon *Gary Ruvkun == See also == *Daf-2 *FOX proteins 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Daf-16」の詳細全文を読む スポンサード リンク
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