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Danaparoid sodium (Orgaran) is an anticoagulant that works by inhibiting activated factor X (factor Xa). Danaparoid is a heparinoid but considered to be a low molecular weight heparin by some sources. However it is chemically distinct from heparin, has different protein binding properties and thus has little cross-reactivity in heparin-intolerant patients. It consists of a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate. ==Uses== It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery. It is also used as a heparinoid substitute in heparin-induced thrombocytopenia (HIT) which may otherwise cause paradoxical thrombosis. Danaparoid is used for thrombosis prophylaxis and treatment in heparin-induced thrombocytopenia patients, although cross-reactivity with heparin-induced antibodies can occur in 10–20% of the patients ((ESRA) ). It has been proposed for use in Kasabach-Merritt syndrome. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Danaparoid」の詳細全文を読む スポンサード リンク
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