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Darapladib
Darapladib is an inhibitor lipoprotein-associated phospholipase A2 (Lp-PLA2) that is in development as a drug for treatment of atherosclerosis.〔Thompson PL et al. Targeting the unstable plaque in acute coronary syndromes. Clin Ther. 2013 Aug;35(8):1099-107. PMID 23973042〕 It was discovered by Human Genome Sciences in collaboration with GlaxoSmithKline (GSK).〔Reuters. 12 April 2007 〕 In November 2013, GSK announced that the drug had failed to meet Phase III endpoints in a trial of 16,000 patients with (coronary syndrome )].〔http://www.fiercebiotech.com/story/glaxosmithkline-loses-its-first-big-phiii-bet-heart-drug-darapladib/2013-11-12〕 An additional trial of 13,000 patients (SOLID-TIMI 52) finished in May 2014. The study failed to reduce the risk of coronary heart disease death, MI, and urgent coronary revascularization compared with placebo in acute coronary syndrome (ACS) patients treated with standard medical care.〔http://www.gsk.com/media/press-releases/2014/gsk-announces-phase-iii-study-with-darapladib-did-not-meet-prima.html〕 ==References==
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