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Decynium-22
Decynium-22 is a cation derivative of quinoline, and a potent inhibitor of the plasma membrane monoamine transporter (PMAT), as well as all members of the organic cation transporter (OCT) family in both human and rat cells.〔(【引用サイトリンク】title=Decynium-22 )〕 However, it has little effect on high affinity monoamine transporters such as the dopamine transporter and norepinephrine transporter. ==Transporter inhibition== Decynium has been shown to have a very high affinity to organic cation transporters in a variety of species, including human, rat, and pig. Decynium-22 has been shown to block the uptake of 1-methyl-4-phenylpyridinium (MPP) via the OCT3 transporter in rat astrocytes.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Decynium-22」の詳細全文を読む
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