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Deferiprone
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Deferiprone : ウィキペディア英語版
Deferiprone

Deferiprone (tradenames include Ferriprox) is a drug that chelates iron and is used to treat iron overload in thalassaemia major.〔 (Full Text ).〕 It was first approved for use in treating thalassaemia major in 1994〔Staff, Cipla. (Cipla's History )〕 and had been licensed for use in Europe and Asia for many years while awaiting approval in Canada and the United States.〔〔http://www.docguide.com/dg.nsf/PrintPrint/F8BC7049D350C2AD852568A2006FEAAC〕 On October 14, 2011, it was approved for use in the US under the FDA’s accelerated approval program.〔FDA NEWS RELEASE: FDA Approves Ferripox (deferiprone) to Treat Patients with Excess Iron in the Body, Oct. 14, 2011 http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm275814.htm〕
==Controversy==
Deferiprone was at the center of a protracted struggle between Nancy Olivieri, a Canadian haematologist and researcher, and the Hospital for Sick Children and the pharmaceutical company Apotex, that started in 1996 and delayed approval of the drug in North America.
Dr. Olivieri's data suggested deferiprone leads to progressive hepatic fibrosis.〔 (Full Text ).〕〔 (Full Text ).〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Deferiprone」の詳細全文を読む



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