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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Dendrin ： ウィキペディア英語版 Dendrin Dendrin is a neural and renal protein whose exact function is still relatively unclear; however, its location in the brain and kidneys is well known as are some of the neural processes it affects. Within the brain, dendrin can be found in neurons and is most notably associated with sleep deprivation. Sleep deprivation causes some areas of the brain dendrin levels to increase, but this increase is insignificant and in total sleep deprivation causes a decrease of the mRNA and protein form of dendrin.〔 Along with two other proteins, MAGI/S-SCAM and α-actinin, dendrin is linked to synaptic plasticity and memory formation in the brain.〔 Nicotine levels have also been shown to have an effect on dendrin expression in the brain. Although unlike sleep deprivation, nicotine increases overall dendrin level.〔 Originally thought to be a brain specific protein, there is now evidence to suggest that dendrin is also found in the kidneys.〔 Dendrin is used to detect glomerulopathy or renal disease, based on its location in the kidneys.〔 Within the kidneys it also works to prevent urinary protein loss.〔 Most studies and information on dendrin pertain specifically to rat or mice brains. ==Structure== Dendrin has a similar structure in mice, rats, and humans.〔 The protein is composed of 2,067 nucleotides, is hydrophilic, and is rich in the animo acid proline. Dendrin is a protein kinase substrate that is composed of multiple consensus sites for phosphorylation by protein kinase C, casein kinase 11, CAMP-dependent and proline-dependent kinases, and tyrosine kinase. Surprisingly, the protein structure does not have any secondary structure patterns, such as lengthy regions of α helices or β sheets.〔 Appropriately named, dendrin in its mRNA form is often found in the dendrites of neurons.〔 The unique structure of dendrin allows it to participate in many different processes, such as synaptic plasticity in the brain and disease detection in the kidneys. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Dendrin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.