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Derlin-1
Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a protein that in humans is encoded by the ''DERL1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79139 )〕 It is a member of the rhomboid-like clan of polytopic membrane proteins. == Function ==
Derlin-1 is part of a complex (that includes VIMP, SEL1, HRD1, and HERP) that mediates endoplasmic-reticulum-associated degradation (ERAD) that detects misfolded proteins in the endoplasmic reticulum and targets them for destruction.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Derlin-1」の詳細全文を読む
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