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Devazepide
Devazepide〔US Patent 4820834〕 (L-364,718, MK-329) is benzodiazepine drug, but with quite different actions from most benzodiazepines, lacking affinity for GABAA receptors and instead acting as an CCKA receptor antagonist.〔Hill DR, Woodruff GN. Differentiation of central cholecystokinin receptor binding sites using the non-peptide antagonists MK-329 and L-365,260. ''Brain Research''. 1990 Sep 3;526(2):276-83. PMID 2257485〕 It increases appetite and accelerates gastric emptying,〔Cooper SJ, Dourish CT. Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are instrumental in the control of feeding. ''Physiology and Behaviour''. 1990 Dec;48(6):849-57. PMID 1982361〕〔Cooper SJ, Dourish CT, Clifton PG. CCK antagonists and CCK-monoamine interactions in the control of satiety. ''American Journal of Clinical Nutrition''. 1992 Jan;55(1 Suppl):291S-295S. PMID 1728842〕 and has been suggested as a potential treatment for a variety of gastrointestinal problems including dyspepsia, gastroparesis and gastric reflux.〔Scarpignato C, Varga G, Corradi C. Effect of CCK and its antagonists on gastric emptying. ''Journal of Physiology Paris''. 1993;87(5):291-300. PMID 8298606〕 It is also widely used in scientific research into the CCKA receptor.〔Weller A. The ontogeny of postingestive inhibitory stimuli: examining the role of CCK. ''Developmental Psychobiology''. 2006 Jul;48(5):368-79. PMID 16770766〕〔Savastano DM, Covasa M. Intestinal nutrients elicit satiation through concomitant activation of CCK(1) and 5-HT(3) receptors. ''Physiology and Behaviour''. 2007 Oct 22;92(3):434-42. PMID 17531277〕
==Synthesis==
Devazepide is synthesised in a similar manner to other benzodiazepines.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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