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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Diarylquinoline ： ウィキペディア英語版 Diarylquinoline Diarylquinolines (DARQs) is a chemical class of drugs that treat tuberculosis, e.g. bedaquiline. The drug targets the subunit c of mycobacterial ATP synthase, inhibiting the enzyme so mycobacterium tuberculosis cannot synthesise ATP. This effectively kills the bacteria. As of 2014, the only licensed indication of the drug bedaquiline is in the treatment of multi-drug-resistant tuberculosis, primarily due to concerns about safety. Although ATP synthase in bacteria is similar to its eukaryotic analogue, diarylquinoline agents are very specific to the bacterial enzyme, so are safe for use in humans and other eukaryotes. This also suggests that ATP synthase inhibition is an attractive therapeutic target〔 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Diarylquinoline」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.