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S-Ethylisothiouronium diethylphosphate
''S''-Ethylisothiouronium diethylphosphate (brand name Difetur) is an ''S''-alkylisothiouronium derivative used as an antihypotensive drug. The ''S''-alkylisothiouronium compounds are used in processes of treating acute hypotension, which may result, for example, from shock or hemorrhage, and in processes for treating hyperoxic conditions, for example, oxygen poisoning.〔Pharmaceutical compositions comprising S-alkylisothiouronium derivatives, http://www.patentgenius.com/patent/6160008.html〕
==Indications==
It is used for increasing arterial blood pressure in cases of acute arterial hypotension due to surgical interference, trauma, poisoning, shock condition,hemorrhages; in conjunction with epidural anesthesia; in overdose of ganglion blockers, alpha-adrenergic blockers, neuroleptics, anesthetics; and in other conditions when adrenomimetics are contra-indicated or ineffective. Difetur was also found to possess oxygen protective activity and, thus, can be used as a medicament for protecting against oxygen poisoning conditions caused by hyperoxia.〔
''S''-Ethylisothiouronium diethylphosphate is also used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting, effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.〔Pharmaceutical compositions for headache, migraine, nausea and emesis; United States Patent 7148208; http://www.freepatentsonline.com/7148208.html〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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