翻訳と辞書 Words near each other ・ Dihydropyran ・ Dihydropyridine ・ Dihydropyrimidinase ・ Dihydropyrimidine dehydrogenase ・ Dihydropyrimidine dehydrogenase (NADP+) ・ Dihydropyrimidine dehydrogenase deficiency ・ Dihydroquinidine ・ Dihydroquinine ・ Dihydrosanguinarine ・ Dihydrosanguinarine 10-monooxygenase ・ Dihydrostilbenoid ・ Dihydrostreptomycin ・ Dihydrostreptomycin-6-phosphate 3'alpha-kinase ・ Dihydrotachysterol ・ Dihydrotanshinone ・ Dihydrotestosterone ・ Dihydrotetrabenazine ・ Dihydrothiepine ・ Dihydrothymine ・ Dihydrouracil ・ Dihydrouracil dehydrogenase (NAD+) ・ Dihydrouracil oxidase ・ Dihydrouridine ・ Dihydroxy-acid dehydratase ・ Dihydroxyacetone ・ Dihydroxyacetone phosphate ・ Dihydroxyacetone synthase ・ Dihydroxyamphetamine ・ Dihydroxyanthraquinone ・ Dihydroxybenzoic acid Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Dihydrotestosterone ： ウィキペディア英語版 Dihydrotestosterone Dihydrotestosterone (commonly abbreviated to DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone (5α-androstan-17β-ol-3-one) as well as 17β-hydroxy-5α-androstan-3-one, is a sex steroid and androgen hormone. The enzyme 5α-reductase synthesizes DHT in the prostate, testes, hair follicles, and adrenal glands. This enzyme reduces the 4,5 double-bond of the hormone testosterone. == Effects on sexual development == In men, approximately 5% of testosterone undergoes 5α-reduction to form the more potent androgen, dihydrotestosterone (DHT). DHT has two to three times greater androgen receptor affinity than testosterone and has 15-30 times greater affinity than adrenal androgens. The dissociation rate of testosterone from the receptor is five-fold faster than DHT. During embryogenesis DHT has an essential role in the formation of the male external genitalia, while in the adult DHT acts as the primary androgen in the prostate and in hair follicles. An example illustrating the significance of DHT for the development of secondary sex characteristics is congenital 5-α-reductase (5-AR) deficiency. This gene lesion can result in pseudohermaphroditism. This condition typically presents with underdeveloped male genitalia and prostate. These individuals are often raised as girls due to their lack of conspicuous male genitalia.〔 In the onset of puberty, although their DHT levels remain very low, their testosterone levels elevate normally. Their musculature develops like that of other male adults. After puberty, men with this condition have a large deficiency of pubic and body hair, and no incidence of male pattern baldness. Unlike other androgens such as testosterone, DHT cannot be converted by the enzyme aromatase to estradiol. Therefore, it is frequently used in research settings to distinguish between the effects of testosterone caused by binding to the androgen receptor and those caused by testosterone's conversion to estradiol and subsequent binding to estrogen receptors. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Dihydrotestosterone」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.