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・ Dock Road Edwardian Pumping Station
・ Dock shunter
・ Dock Square (Boston)
・ Dock Street Brewing Company
・ Dock Street Dam
・ Dock Street Theatre
・ Dock Sud
・ Dock Tarn
・ Dock Walloper
・ Dock Walsh
・ Dock warrant
・ Dock Work Convention, 1973
・ Dock, Wharf, Riverside and General Labourers' Union
・ Dock10
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Dock180
・ Dock2
・ Dock3
・ Dock4
・ Dock4-Ex49
・ Dock5
・ Dock6
・ Dock7
・ Dock8
・ DOCK8 deficiency
・ Dock9
・ Dockage
・ Dockanema
・ Dockapps
・ Dockendorf


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Dock180 : ウィキペディア英語版
Dock180

Dock180, (Dedicator of cytokinesis) also known as DOCK1, is a large (~180 kDa) protein involved in intracellular signalling networks.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1793 )〕 It is the mammalian ortholog of the ''C. elegans'' protein CED-5 and belongs to the DOCK family of Guanine nucleotide exchange factors (GEFs).
==Discovery==
Dock180 was identified, using a far-western blotting approach, as a binding partner of the adaptor protein Crk that was able to induce morphological changes in 3T3 fibroblasts. Subsequently it was reported that Dock180 was able to activate the small GTP-binding protein (G protein) Rac1 and this was later shown to happen via its ability to act as a GEF.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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