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・ Dzhanbulak
・ Dzhandzhan
・ Dzhanek
・ Dzhangi
・ Dzhangi-Tau
・ Dyzin
・ Dyzio
・ Dyzma Gałaj
・ Dyé
・ DZ
・ Dz (digraph)
・ DZ Bank
・ DZ Bank building
・ DZ Deathrays
・ DZ Flash
Dz13
・ DZA
・ DZAC-TV
・ DZAD-TV
・ DZAE-TV
・ Dzafič
・ Dzagyel
・ Dzahadjou
・ Dzahadjou Lamzandé
・ Dzahani
・ Dzahui
・ Dzair News
・ Dzair TV
・ Dzala ertobashia
・ Dzala language


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Dz13 : ウィキペディア英語版
Dz13
Dz13 is an experimental treatment developed by scientists at the University of New South Wales. The drug aims to combat a range of illnesses, including skin cancer, restenosis, arthritis and macular degeneration.
==Mechanism of action==
Dz13 is a 10-23 DNAzyme that targets c-Jun, a transcription factor found in diseased blood vessels, eyes, lungs and joints. The treatment works by the DNA-based enzyme binding to and catalytically destroying its target messenger RNA, thereby inhibiting c-Jun expression in cells.〔
Dz13 has underpinned the development of a library of programmable DNAzymes operable in a cellular environment. 〔
The potential of Dz13 as a therapeutic agent derives from the fact that inactivation of c-Jun can have an effect on downstream genes such as MMP-2, MMP-9, VEGF and FGF-2.〔〔 Dz13 also inhibits the expression of pro-inflammatory cytokines such as TNF-alpha, interferon gamma and IL-6.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Dz13」の詳細全文を読む



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