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E124 : ウィキペディア英語版
Ponceau 4R

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Ponceau 4R (known by more than 100 synonyms,〔Abbey J, et at. Colorants. pp 459-465 in Encyclopedia of Food Safety, Vol 2: Hazards and Diseases. Eds, Motarjemi Y et al. Academic Press, 2013. ISBN 9780123786135〕 including as C.I. 16255,〔FDA. 9 November 2008. (Food and Drug Administration Compliance Program Guidance Manual, Chapter 03 - Foodborne Biological Hazards ) p37〕 Cochineal Red A,〔 C.I. Acid Red 18,〔 Brilliant Scarlet 3R,〔 Brilliant Scarlet 4R,〔 New Coccine,〔 is a synthetic colourant that may be used as a food colouring. It is denoted by E Number E124.〔 Its chemical name is 1-(4-sulpho-1-napthylazo)- 2-napthol- 6,8-disulphonic acid, trisodium salt. Ponceau (French for "poppy-coloured") is the generic name for a family of azo dyes.
Ponceau 4R is a strawberry red azo dye which can be used in a variety of food products, and is usually synthesized from aromatic hydrocarbons; it is stable to light, heat, and acid but fades in the presence of ascorbic acid.〔
It is used in Europe, Asia and Australia, but has not been approved by the US FDA.〔〔
== Health effects ==
There is no evidence of carcinogenicity, genotoxicity, neurotoxicity, or reproductive and developmental toxicity at the permitted dietary exposures; the European acceptable daily intake (ADI) is 0.7 mg/kg and the WHO/FAO ADI is 4 mg/kg.〔
The production process may result in unsulphonated aromatic amines present in concentrations of up to 100 mg/kg which may be linked to cancer. The lake pigment form of the colour additive can also increase the intake of aluminium beyond the tolerable weekly intake (TWI) of 1 mg/kg/week. Therefore the limit for aluminium may be adjusted to accommodate for this.〔EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) (091113 efsa.europa.eu Scientific Opinion on the re-evaluation of Ponceau 4R (E 124) as a food additive ) EFSA Journal 2009; 7(11):1328〕

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