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E1R
E1R is a 4,5-disubstituted derivative of piracetam and a positive allosteric modulator of the sigma-1 receptor. It is a racetam and is the (4''R'',5''S'') stereoisomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide.〔 It differs from phenylpiracetam by having a methyl group.〔 E1R enhances cognition and has efficacy against cholinergic dysfunction in mice without affecting locomotor activity.〔 ==Effects== Pretreatment with E1R enhanced the σ1R agonist PRE-084's stimulating effect and facilitated passive avoidance retention.〔 It alleviated scopolamine-induced cognitive impairment.〔 Because E1R had no effect on locomotor activity, it was found to be free of potential motor side effects.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「E1R」の詳細全文を読む
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