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EBC-46 is a experimental drug candidate being studied pre-clinically by the Australian company Ecobiotics (specifically its drug discovery subsidiary Qbiotics). It was discovered through an automated screening process of natural products by selecting increasingly purified fractions of plant extracts, based on their ability to produce the desired activity profile. This is then followed by artificial synthesis of the isolated compound to confirm its chemical structure. EBC-46 is a phorbol ester which, along with other related compounds, acts as a protein kinase C regulator. The initial lead came from observation that marsupials found the seed of ''Fontainea picrosperma'' unpalatable due to an inflammatory chemical present in reasonably high concentrations. This was identified as 12-tigloyl-13-(2-methylbutanoyl)-6,7-epoxy-4,5,9,12,13,20-hexahydroxy-1-tiglian-3-one.〔(Tiglian-3-one derivatives. Patent WO 2007/070985 )〕 ECB-46 is an extract from the blushwood berries of Queensland, Australia. ==See also== * PEP005 * Thapsigargin 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「EBC-46」の詳細全文を読む スポンサード リンク
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