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Estrogen-related receptor gamma
Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2104 )〕 It behaves as a constitutive activator of transcription.〔
This protein is a member of nuclear hormone receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG. It also seems to be the target of bisphenol A (see below).
==Bisphenol A binding==
There is evidence that bisphenol A functions as an endocrine disruptor by binding strongly to ERR-γ.〔 BPA as well as its nitrated and chlorinated metabolites seems to binds strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER).,〔 BPA binding to ERR-γ preserves its basal constitutive activity.〔 It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.
Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta, explaining reports of high bisphenol A accumulation there.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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