翻訳と辞書 Words near each other ・ Ezetimibe/atorvastatin ・ Ezetimibe/simvastatin ・ EZF ・ EZFW ・ EZGenerator ・ Ezgi ・ Ezgi Asaroğlu ・ Ezgi Dilik ・ Ezgi Mola ・ Ezgi Çağlar ・ Ezginin Günlüğü ・ Ezgjan Alioski ・ Ezh ・ Ezh with caron ・ EZH1 ・ EZH2 ・ Ezha ・ Ezhacherry Ramachandran ・ Ezhai Jaathi ・ Ezhai Padum Padu ・ Ezhai Pangalan ・ Ezham Rathri ・ Ezham Suryan ・ Ezhamathe Varavu ・ Ezhamedam ・ Ezhamkadalinakkare ・ Ezhamkulam ・ Ezhana Wolene ・ Ezhantsy ・ Ezhara Ponnana Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク EZH2 ： ウィキペディア英語版 EZH2 Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in DNA methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2 facilitates heterochromatin formation thereby silences gene function.〔 Remodeling of chromosomal heterochromatin by EZH2 is also required during cell mitosis. EZH2 is the functional enzymatic component of the polycomb repressive complex 2 (PRC2), which is responsible for healthy embryonic development through the epigenetic maintenance of genes responsible for regulating development and differentiation. EZH2 is responsible for the methylation activity of PRC2, and the complex also contains proteins required for optimal function (EED, SUZ12, JARID2, AEBP2, RbAp46/48, and PCL). EZH2 inhibits genes responsible for suppressing tumor development, and blocking EZH2 activity may slow tumor growth. EZH2 has been targeted for inhibition because it is upregulated in multiple cancers including, but not limited to, breast, prostate, melanoma, and bladder cancer. Mutations in the EZH2 gene are also associated with Weaver syndrome, a rare congenital disorder, and EZH2 is involved in causing neurodegenerative symptoms in the nervous system disorder, ataxia telangiectasia. == Function == EZH2 is the catalytic subunit of the Polycomb repressive complex 2 (PRC2).〔UniProt: 〕 EZH2's catalytic activity relies on its formation of a complex with at least two other PRC2 components, SUZ12 and EED.〔 As a histone methyltransferase (HMTase), EZH2's primary function is to methylate Lys-27 on histone 3 (H3K27me) by transferring a methyl group from the cofactor S-adenosyl-L-methionine (SAM), although recent studies have indicated that it is also capable of methylating non-histone proteins. EZH2 is capable of mono-, di-, and tri-methylation of H3K27 and has been associated with a variety of biological functions, including transcriptional repression and activation, hematopoiesis, development, and cell differentiation.〔〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「EZH2」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.