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Edotreotide
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Edotreotide : ウィキペディア英語版
Edotreotide
chembox
| Verifiedfields = changed
| verifiedrevid = 458457286
| ImageFile = DOTATOC.png
| ImageName =
| IUPACName = 2--7-()-16-()-13-(1''H''-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
" TITLE="(4''R'',7''S'',10''S'',13''R'',16''S'',19''R'')-10-(4-aminobutyl)-4-(2''R'',3''R'')-1,3-dihydroxybutan-2-yl]carbamoyl]-7-()-16-()-13-(1''H''-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
"> OtherNames =
labelled edotreotide" TITLE="(2''R'')-1-)-16-()-13-(1''H''-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
" TITLE="
(4''R'',7''S'',10''S'',13''R'',16''S'',19''R'')-10-(4-aminobutyl)-4-(2''R'',3''R'')-1,3-dihydroxybutan-2-yl]carbamoyl]-7-()-16-()-13-(1''H''-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
"> OtherNames =
labelled edotreotide">(2''R'')-1-)-16-()-13-(1''H''-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
" TITLE="
(4''R'',7''S'',10''S'',13''R'',16''S'',19''R'')-10-(4-aminobutyl)-4-(2''R'',3''R'')-1,3-dihydroxybutan-2-yl]carbamoyl]-7-()-16-()-13-(1''H''-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
"> OtherNames =
labelled edotreotide
Edotreotide (USAN, codenamed SMT487, also known as (DOTA0-Phe1-Tyr3)octreotide, or DOTATOC) is a substance which, when bound to various radionuclides, is used in the treatment and diagnosis of certain types of cancer.〔Martindale, The Extra Pharmacopoeia, 30th ed, p1161.〕
It has been the subject of a trial by the National Cancer Institute to determine its effects in young cancer patients (up to 25 years of age) for its ability to locate malignant cancer cells without harming normal cells. Specific cancers being included in the trial include neuroblastoma, childhood brain tumours and gastrointestinal cancer.〔(Radiolabeled Octreotide in Treating Children With Advanced or Refractory Solid Tumors )〕
==See also==

* DOTA-TATE, a similar compound

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Edotreotide」の詳細全文を読む



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