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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Eledoisin ： ウィキペディア英語版 Eledoisin chembox | ImageFile = Eledoisin skeletal.svg | ImageFile1 = PDB 1mxq EBI.jpg | IUPACName = (3''S'')-3-pyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-4-(2''S'')-1-(2''S'')-1-(2''S'',3''S'')-1-2-(2''S'')-1-(2''S'')-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid " TITLE="(2''S'')-3-hydroxy-2-(2''S'')-1-()pyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-4-(2''S'')-1-(2''S'')-1-(2''S'',3''S'')-1-2-(2''S'')-1-(2''S'')-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid "> OtherNames = of mollusk origin, belonging to the tachykinin family of neuropeptides. It was first isolated from the posterior salivary glands of two mollusk species ''Eledone muschata'' and ''Eledone aldovandi'', which belong to the octopod order of Cephalopoda. 〔De Marco, A., and G. Gatti, "1H- and 13C-NMR spectra of eledoisin and intermediate oligopeptides." ''Int. J. Pep. Pro. Res.'' 7:437–444, 1975.〕 Other tachykinins from nonmammalian sources include kassinin and physalaemin. The mammalian tachykinins substance P, NKA, and NKB have similar effects as tachykinins of nonmammals and have been more widely studied and characterized. These peptides exhibit a wide and complex spectrum of pharmacological and physiological activities such as vasodilation, hypertension, and stimulation of extravascular smooth muscle.〔R. Christy Rani Grace, Indu R. Chandrashekar and Sudha M. Cowsik, ("Solution Structure of the Tachykinin Peptide Eledoisin" ), ''Biophysical Journal'' 84:655-664 (2003), retrieved 05 Dec 2007. This publication has excellent general information on the eledoisin molecule.〕 Eledoisin has the (acid sequence )] pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH. Like all tachykinin peptides, Eledoisin shares the same consensus C-terminal sequence, that is, Phe-Xxx-Gly-Leu-Met-NH. The invariant "Phe7" residue is probably required for receptor binding. "Xxx" is either an aromatic (phenylalanine, tyrosine) or a branched aliphatic (valine, isoleucine) side chain and is thought to be important in receptor selectivity. This common region, often referred to as the "message domain," is believed to be responsible for activating the receptor. The divergent N-terminal region or the "address domain" varies in amino-acid sequence and length and is believed to play a role in determining the receptor subtype specificity. 〔Schwyzer, R., "Membrane-assisted molecular mechanism of neurokinin receptor subtype selection." ''EMBO J.'' 6:2255–2259, 1987〕 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Eledoisin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.