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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Endoexocytosis ： ウィキペディア英語版 Endoexocytosis Endoexocytosis is a cellular process.〔Nickel BM, DeFranco BH, Gay VL, Murray SA. Clathrin and Cx43 Gap Junction Plaque Endoexocytosis. Biochemical & Biophysical Research Communications 2008;374:679-682.〕 It is a unique internalization process in which the two opposing gap junction plaque membranes are internalized into one of two contacting cells, to form pentilaminar-annular gap junction vesicles.〔Larsen WJ, Hai N. Origin and fate of cytoplasmic gap junctional vesicles in rabbit granulosa cells. Tissue & Cell 1978;10:585-98.〕〔Murray SA, Larsen WJ, Trout J, Donta ST. Gap junction assembly and endocytosis correlated with patterns of growth in a cultured adrenocortical tumor cell (SW-13). Cancer Res 1981;41:4063-74.〕〔Jordan K, Chodock R, Hand AR, Laird DW. The origin of annular junctions: a mechanism of gap junction internalization. J Cell Sci 2001;114:763-73.〕 In non-gap junctional membrane internalization, endocytosis can occur independent of the conditions in adjacent cells. However in the case of gap junction plaque internalization the membrane of the adjacent cell is internalized into its contacting cell pair, and is thus an “endoexocytic” process. It has been previously suggested that gap junction plaque internalization is mediated by clathrin and its associated proteins.〔Larsen WJ, Tung HN, Murray SA, Swenson CA. Evidence for the participation of actin microfilaments and bristle coats in the internalization of gap junction membrane. J Cell Biol 1979;83:576-87.〕〔Leithe E, Rivedal E. Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. J Cell Sci 2004;117:1211-20.〕〔Piehl M, Lehmann C, Gumpert A, Denizot JP, Segretain D, Falk MM. Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process. Mol Biol Cell 2007;18:337-47.〕 This hypothesis was supported initially, by the presence of the bristle-like coat surrounding annular gap junction vesicles and later by the demonstration of the light microscopic immunocytochemical and transmission electron microscopic quantum dot colocalization of clathrin and Cx43-GFP structures.〔Piehl M, Lehmann C, Gumpert A, Denizot JP, Segretain D, Falk MM. Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process. Mol Biol Cell 2007;18:337-47.〕〔Nickel BM, DeFranco BH, Gay VL, Murray SA. Clathrin and Cx43 Gap Junction Plaque Endoexocytosis. Biochemical & Biophysical Research Communications 2008;374:679-682.〕 The reports of a decreased number of annular gap junctions following treatments that disrupt clathrin activity provided additional support for a role of clathrin in gap junction plaque internalization and annular gap junction formation.〔Leithe E, Rivedal E. Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43. J Cell Sci 2004;117:1211-20.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Endoexocytosis」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.