翻訳と辞書 Words near each other ・ Ephrath ・ Ephraïm Inoni ・ Ephrem (name) ・ Ephrem Ashamo ・ Ephrem de Nevers ・ Ephrem Giesen ・ Ephrem M'Bom ・ Ephrem Mtsire ・ Ephrem of Crimea ・ Ephrem the Syrian ・ Ephriam DuPuy Stone House ・ Ephriam M. Baynard House ・ Ephrin ・ Ephrin A1 ・ Ephrin receptor ・ Ephrin-A5 ・ Ephron ・ Ephrussi family ・ EPHS ・ EPHX1 ・ Ephydra hians ・ Ephydridae ・ Ephydroidea ・ Ephyra ・ Ephyriades ・ Ephyriades arcas ・ Ephyrodes ・ Ephysius ・ Ephysteris ・ Ephysteris accentella Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Ephrin-A5 ： ウィキペディア英語版 Ephrin-A5 Ephrin-A5 is a protein that in humans is encoded by the ''EFNA5'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1946 )〕 Ephrin-A5 is a glycosylphosphatidylinositol (GPI)-anchored protein of the ephrin-A subclass of ephrin ligands that binds to the EphA subclass of Eph receptors. Ephrin-A5 has also been shown to bind to the EphB2 receptor. == Reverse signaling in growth cone survival == "Reverse" signaling is one unique property of ephrin ligands that allows for the transmission of an intracellular signal in ephrin-expressing cells that is distinct from the signal transmitted in Eph receptor-expressing cells. Although the mechanism of "reverse" signaling by ephrin-As is not well understood, it is relatively surprising considering that ephrin-A ligands are attached to the cell membrane solely by a GPI linkage and unlike ephrin-Bs, lack a potential intracellular signaling domain. Nonetheless, certain ephrin-A ligands are known to initiate reverse signaling cascades like ephrin-A5, which has been shown to stimulate the spreading of growth cones in cultures of mouse spinal motor neurons. Interestingly, reverse signaling by ephrin-A5 was demonstrated to be GPI-dependent as the elimination of all GPI linkages by the application of a phosphatidlyinositol-specific phospholipase C abolished the positive effects of ephrin-A5 on growth cone spreading. Additionally, EphA receptors were shown to exert opposite effects on motor neuron growth cones by reducing growth cone size. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Ephrin-A5」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.