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Ergoline
Ergoline is a chemical compound whose structural skeleton is contained in a diverse range of alkaloids. Ergoline derivatives are used clinically for the purpose of vasoconstriction (5-HT1 receptor agonists—ergotamine) and in the treatment and alleviation of migraines (used with caffeine) and Parkinson's disease. Some ergoline alkaloids found in ergot fungi are implicated in the condition ergotism, which causes convulsive and gangrenous symptoms. Others are psychedelic psychoactive substances, including LSD, lysergic acid and some alkaloids in ''Ipomoea tricolor'' and related species .
==Uses==
In addition to the naturally occurring ergonovine (used as an oxytocic) and ergotamine (a vasoconstrictor used to control migraine), synthetic derivatives of importance are the oxytocic methergine, the anti-migraine drugs dihydroergotamine and methysergide, hydergine (a mixture of dihydroergotoxine mesylates, INN: ergoline mesylates), and bromocriptine, used for numerous purposes including treatment of Parkinson's disease. Newer synthetic ergolines used for Parkinson's disease include pergolide and lisuride.
Perhaps the most famous ergoline derivative is the psychedelic drug LSD. Ergometrine and ergotamine are included as schedule I precursors in the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.〔(http://www.incb.org/pdf/e/list/red.pdf ).〕
Ergolines can pass into breast milk and should not be used during breastfeeding.〔(kidsgrowth.org --> Drugs and Other Substances in Breast Milk ) Retrieved on June 19, 2009.〕 They are uterine contractors that can increase the risk of miscarriage during pregnancy.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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