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Eszopiclone : ウィキペディア英語版
Eszopiclone

Eszopiclone, marketed by Sunovion under the brand-name Lunesta, is a nonbenzodiazepine hypnotic which is slightly effective for insomnia.〔 Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrolones.
Eszopiclone (Lunesta) along with other "Z-drugs" including zolpidem (Ambien), zaleplon (Sonata) are the most commonly prescribed sedative hypnotics in the United States. Eszopiclone is not marketed in the European Union following a 2009 decision by the EMA denying it ''new active substance'' status,〔(Sepracor Pharmaceuticals Ltd withdraws its marketing authorisation application for Lunivia (eszopiclone) ) – EMA, 15 May 2009〕 in which it ruled that eszopiclone was too similar to zopiclone to be considered a new patentable product.〔(End of Sepracor-GSK Deal Raises Question in Lunesta Patent Fight ) – CBS/BNet, 13 Jun 2009〕
Eszopiclone is now available in a generic form in the United States as of May 2014. On May 15, 2014, the USFDA asked that the starting dose of Eszopiclone (Lunesta) be lowered from 2 milligrams to 1 milligram after it was observed in a study that even 8 hours after taking the drug at night, some patients were not able to cope with their next-day activities like driving and other activities that require full alertness.〔(FDA requiring lower starting dose for drug Eszopiclone (Lunesta) )〕
==Medical uses==
Eszopiclone is slightly effective in the treatment of insomnia where difficulty in falling asleep is the primary complaint. Kirsch et al. found the benefit over placebo to be of questionable clinical significance.〔 Although the drug effect and the placebo response were rather small and of questionable clinical importance, the two together produce a reasonably large clinical response.〔 It is not recommended for chronic use in the elderly.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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