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Aspirin/paracetamol/caffeine
Aspirin/paracetamol/caffeine is a combination drug for the treatment of pain, especially tension headache and migraine.〔Drugs.com: 〕 It is sold in the US under the trade name Excedrin, although not all products sold under this name contain this combination.
==Adverse effects==
The recommended dosing has a low risk profile when taken occasionally in a well hydrated state. As with all medications containing paracetamol (acetaminophen), concomitant use with alcohol carries a significant risk of hepatotoxicity. The combination of paracetamol with aspirin also creates the risk of renal papillary necrosis if large doses are taken chronically. This is because paracetamol yields a toxic metabolite that can accumulate in the kidney while aspirin works to deplete the glutathione stores necessary to oxidize it. Additionally, chronic aspirin usage is associated with increased risk of gastrointestinal bleeding.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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