翻訳と辞書 Words near each other ・ Flexure bearing ・ FlexWage Solutions ・ FlexWiki ・ Fley ・ Fleys ・ Flez-Cuzy ・ Fleșcuța River ・ Fleștenoaga River ・ Fleț River ・ FLF ・ FLG ・ Flg-Rhizobiales RNA motif ・ Flhorban 920 (banana cultivar) ・ FLHS ・ FLI ・ FLI1 ・ Fli4l ・ Flia ・ Fliballie ・ Flibanserin ・ Flibbertigibbet ・ Flibbiddydibbiddydob ・ Flibbix ・ FLiBe ・ Flibe Energy ・ FLIC ・ FLIC (file format) ・ Flic Story ・ Flic-en-Flac ・ FLICAM Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク FLI1 ： ウィキペディア英語版 FLI1 Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the ''FLI1'' gene, which is a proto-oncogene. == Function == Fli-1 is a member of the ETS transcription factor family that was first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F-MuLV). Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias. The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「FLI1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.