翻訳と辞書 Words near each other ・ Foxleigh ・ Foxleigh coal mine ・ Foxley ・ Foxley (disambiguation) ・ Foxley (surname) ・ Foxley River, Prince Edward Island ・ Foxley Wood ・ Foxley Wood, Purley ・ FOXM1 ・ Foxmail ・ Foxman ・ Foxmask ・ FOXN1 ・ FOXN3 ・ Foxnet ・ FOXO1 ・ FOXO3 ・ FOXO4 ・ Foxon Park ・ FOXP1 ・ FOXP2 ・ FOXP3 ・ FOXP4 ・ FoxPro ・ FOXRED1 ・ Foxrock ・ FOXSI Sounding Rocket ・ Foxsons Mill, Staincliffe ・ Foxsports.com ・ Foxstar Productions Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク FOXO1 ： ウィキペディア英語版 FOXO1 Forkhead box protein O1 (FOXO1) also known as forkhead in rhabdomyosarcoma is a protein that in humans is encoded by the ''FOXO1'' gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. It is primarily regulated through phosphorylation on multiple residues; its transcriptional activity is dependent on its phosphorylation state. == Mechanism of action == In its un-phosphorylated state, FOXO1 is localized to the nucleus, where it binds to the insulin response sequence located in the promoter for glucose 6-phosphatase and increases its rate of transcription. FOXO1, through increasing transcription of glucose-6-phosphatase, indirectly increases the rate of hepatic glucose production. However, when FOXO1 is phosphorylated by Akt on Thr-24, Ser-256, and Ser-319, it is excluded from the nucleus, where it is then ubiquitinated and degraded. The phosphorylation of FOXO1 by Akt subsequently decreases the hepatic glucose production through a decrease in transcription of glucose 6-phosphatase. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「FOXO1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.