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FOXO4
Forkhead box protein O4 is a protein that in humans is encoded by the ''FOXO4'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4303 )〕 It is located on the long arm of the X chromosome from base pair 71,096,148 to 71,103,533.〔http://ghr.nlm.nih.gov/gene/FOXO4#location〕
== Structure and function ==
FOXO4 is a member of the forkhead family transciption factors O subclass, which is characterized by a winged helix domain used for DNA binding. There are 4 members of the FOXO family, including FOXO1, FOXO3, and FOXO6. Their activity is modified by many post translational activities, such as phosphorylation, ubiquitination, and acetylation. Depending on this modified state, FOXO4 binding affinity for DNA is altered, allowing for FOXO4 to regulate many cellular pathways including oxidative stress signaling, longevity, insulin signaling, cell cycle progression, and apoptosis. Two of the main upstream regulators of FOXO4 activity are phosphoinositide 3- kinase (PI3K) and serine/threonine kinase AKT/PKB. Both PI3K and AKT modify FOXO4 and prevent it from translocating to the nucleus, effectively preventing the transcription of the downstream FOXO targets.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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