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Fenbendazole
Fenbendazole (Hoechst brand names ''Panacur'' and ''Safe-Guard'', Intervet ''Panacur'' and ''Panacur Rabbit'') is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if salicylanilides like dibromsalan and niclosamide are co-adminstered. Abortions in cattle and death in sheep have been reported.〔''Plumb's Veterinary Drug Handbook'', Fifth Edition, 2005.〕
==Toxicity==
Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing. Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.
Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The in laboratory animals exceeds 10 g/kg when administered orally.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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