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Fenproporex
Fenproporex (Perphoxene) is a stimulant drug of the phenethylamine and amphetamine chemical classes which was developed in the 1960s. It is used as an appetite suppressant for the treatment of obesity.〔Warembourg H, Jaillard J. Clinical experimentation with fenproporex in the treatment of obesity. Apropos of 40 cases. (French). ''Journal de la Faculte de médecine et de pharmacie de l'Universite de Lille''. 1968 Mar;13(3):Suppl:273-6.〕
Fenproporex produces amphetamine as a metabolite,〔Tognoni G, Morselli PL, Garattini S. Amphetamine concentrations in rat brain and human urine after fenproporex administration. ''European Journal of Pharmacology''. 1972 Oct;20(1):125-6.〕〔Cody JT. Metabolic precursors to amphetamine and methamphetamine. ''Forensic Science Reviews'' 1993; 5:109.〕 and was withdrawn in many countries following problems with abuse,〔Pelissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, Giocanti D, Leonetti G. Abusive prescription of psychostimulants: a study of two cases. ''Journal of Forensic Science''. 2006 Mar;51(2):407-10.〕 but it is still prescribed in some countries. It is sometimes combined with benzodiazepines, antidepressants and other compounds to create the "Brazilian diet pill".〔Cohen PA. Imported fenproporex-based diet pills from Brazil: a report of two cases. Journal of General Internal Medicine 2009; 24(3):430-3.〕〔Cohen PA, McCormick D, Casey C, Dawson G, Hacker KA. Imported compounded diet pill use among Brazilian women immigrants in the United States. Journal of Immigrant and Minority Health 2009; 11(3):229-236.〕
Fenproporex has never been approved by the US Food and Drug Administration (FDA) for sale in the US due to lack of efficacy and safety data. However, in March 2009 the FDA warned consumers that it has been detected as an unlabeled component of diet pills available over the Internet.〔http://www.fda.gov/cder/consumerinfo/weight_loss_products.htm〕 Fenproporex is designated a Schedule IV controlled substance in the US pursuant to the Controlled Substances Act.〔(【引用サイトリンク】 21 CFR 1308.14(e)(4) )〕
Fenproporex is on the list of substances banned by the World Anti-Doping Agency, and any sportsperson testing positive for the substance faces a ban from competition.〔(The 2009 Prohibited List International Standard ). World Anti-Doping Agency (2009). Retrieved on 2009-08-18.〕
== References ==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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