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Fluproquazone : ウィキペディア英語版
Fluproquazone

Fluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz.〔Haanaes HR, et al RF 46-790 versus paracetamol: effect on post-operative pain. Int J Clin Pharmacol Ther Toxicol. 1986 Nov;24(11):598-601. PMID 3491794〕〔Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. ''Arzneimittelforschung''. 1981;31(5a):918-20.〕〔Wheatley D. Analgesic properties of fluproquazone. ''Rheumatology and Rehabilitation''. 1982 May;21(2):98-100.〕〔Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. ''Arzneimittelforschung''. 1981;31(5a):934-5.〕 It was withdrawn during development due to liver toxicity.〔Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists, Ch 22 in Drug-induced Liver Disease (Third Edition). Eds Neil Kaplowitz and Laurie D. DeLeve. Elsevier Inc, 2013. ISBN 9780123878175〕〔Hyman J. Zimmerman. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. Lippincott Williams & Wilkins, 1999. ISBN 9780781719520〕
== References ==




抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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