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Fluridone
Fluridone is an aquatic herbicide often used to control invasive plants. It is sold under the names ''Sonar'', ''Avast!'' and ''Whitecap'' and is used in the United States to control hydrilla and Eurasian watermilfoil among other species. It is a systemic herbicide that works by interfering with carotene formation which leads to chlorophyll degradation.〔(Fluridone: herbicide treatment FAQ ), Cornell Cooperative Extension Tompkins County, July 17, 2013〕 Fluridone is sold as a liquid and as a slow release solid because the herbicide level must be maintained for several weeks.
The chemical was first reported as a possible herbicide for cotton fields in 1976.〔(1-Methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone, a new herbicide ), Thomas W. Waldrep, Harold M. Taylor, J. Agric. Food Chem., 1976, 24 (6), pp 1250–1251, DOI: 10.1021/jf60208a047, November 1976〕 It was registered with the U.S. Environmental Protection Agency in 1986 and has low toxicity to animals〔(Fluridone - Human Health and Ecological Risk Assessment - Final Report ), Syracuse Environmental Research Associates for USDA/Forest Service, Southern Region, November 25, 2008〕 with no restrictions on swimming or drinking in treated water bodies.〔(Report of the Food Quality Protection Act (FQPA) Tolerance Reassessment Progress and Risk Management Decision (TRED) for Fluridone ), UNITED STATES ENVIRONMENTAL PROTECTION AGENCY, September 20, 2004〕 Fluridone breaks downs in the environment over days or weeks with the major degradation product being N-methyl formamide. The half-life of fluridone in soils and sediments is nine months.
==Pharmaceutical ==
Fluridone's main action to disrupt photosynthesis in plants is by preventing the secretion of abscisic acid. As higher Eukaryotes, such as humans, also rely on an abscisic acid pathway to create inflammation in normal physiological processes, fluridone can be used as an anti-inflammatory drug for humans.
The FDA has listed fluridone in its list of herbicides with a dual role as a pharmaceutical. Fluridone has not been evaluated for safety since this information was presented. Fluridone has been banned in the EU and Japan.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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