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FoldX
FoldX is a protein design algorithm that uses an empirical force field. It can determine the energetic effect of point mutations as well as the interaction energy of protein complexes (including Protein-DNA). FoldX can mutate protein and DNA side chains using a probability-based rotamer library, while exploring alternative conformations of the surrounding side chains. == Applications ==
* Prediction of the effect of point mutations or human SNPs on protein stability or protein complexes * Protein design to improve stability or modify affinity or specificity * Homology modeling
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