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Fosinopril : ウィキペディア英語版
Fosinopril

Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure. Fosinopril is the only phosphinate-containing ACE inhibitor marketed, by Bristol-Myers Squibb under the trade name Monopril.
==Fosinoprilat and fosinopril==
Fosinoprilat proved to have the same problem as enalaprilat and the other carboxylate-containing ACE inhibitors (namely poor oral bioavailability). Addition of a hydrophobic side-chain modulated the ionisation characteristics of the molecule, making it more bioavailable. Fosinopril is administered as a prodrug and is converted ''in vivo'' to the active form fosinoprilat.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Fosinopril」の詳細全文を読む



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