| 翻訳と辞書 |
Fostedil
Fostedil (A-53,986, KB-944) is a vasodilator acting as a calcium channel blocker which was under development for the treatment of heart conditions such as angina pectoris but was never marketed. It has antihypertensive and antiarrhythmic effects.
== Synthesis ==
#Treatment of benzanilide with phosphorus pentasulfide or Lawesson's reagent gives thioamide.
#Oxidative ring formation by reaction with potassium ferricyanide and base (presumably involving a free radical intermediate) constructs the benzothiazole ring.
#Bromination of this compound with N-bromosuccinimide produces bromomethyl intermediate.
#The synthesis of fostedil concludes with a Michaelis-Arbuzov reaction with triethyl phosphite.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「Fostedil」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|