翻訳と辞書 Words near each other ・ Fryszerka, Radomsko County ・ Frysztak ・ Frysztat County ・ Fryton ・ Frytown ・ Frytown, California ・ Frytown, Iowa ・ Fryup ・ Frywałd ・ Fryxell ・ Fryxell (crater) ・ Fryčovice ・ Fryšava pod Žákovou horou ・ Fryšták ・ Fryštát ・ Frzb ・ Frá dauða Sinfjötla ・ Frá Fornjóti ok hans ættmönnum ・ Fráech ・ Fráech mac Finchada ・ Frágil ・ Fráter–Seebach alkylation ・ Fráňa Šrámek ・ Frânca River ・ Frâncești ・ Frâncu River ・ Frânturi River ・ Frâu River ・ Fräkmündt ・ Frälsningsarméns Scoutförbund Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Frzb ： ウィキペディア英語版 Frzb Frzb (pronounced like the toy ''frisbee'') is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. Frizzled is a tissue polarity gene in ''Drosophila melanogaster'' and encodes integral proteins that function as cell-surface receptors for Wnts called serpentine receptors. The integral membrane proteins contain a cysteine-rich domain thought to be the Wnt binding domain in extracellular region. The signals are initiated at the 7 transmembrane domain and transmitted through receptor coupling to G-proteins. The mammal homolog to Frizzled is a frizzled-related protein known as frzb. This protein is expressed in chondrocytes making it important in skeletal development in the embryo and fetus. Frzb is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling. The CRD is highly conserved in diverse proteins, such as receptor tyrosine kinases and functions as a ligand binding domain. The C-terminal is a carboxyl terminus located intracellularly and is required for canonical signaling. The serpentine receptors (frzb) couple binds to ligand (Wnt protein) and activates G-proteins. A signal transduction cascade results in the secretion of first and second group antagonists. First group antagonists are composed of secreted Frizzled Related protein family (Sfrp) and Wnt inhibitory factor (Wif). Both Srfp and Wif bind directly to Wnt proteins blocking activation of the receptor. Second group of antagonists contains a class of Wnt inhibitory proteins known as Frizzled Receptor-like Proteins (FRPs). FRPs bind to the LRP (low-density-lipoprotein-related protein) co-receptors blocking activation of the Wnt signaling pathway. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Frzb」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.