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FtsA is a bacterial protein that is related to actin by overall structural similarity and in its ATP binding pocket. 〔 〕 Along with other bacterial actin homologs such as MreB, ParM, and MamK, these proteins suggest that eukaryotic actin has a common ancestry. Like the other bacterial actins, FtsA binds ATP and can form actin-like filaments. The FtsA-FtsA interface has been defined by structural as well as genetic analysis.〔 Another subdomain of FtsA (2B) is required for interactions with FtsZ, via the conserved C-terminus of FtsZ Other FtsZ regulators including MinC and ZipA bind to the same C terminus of FtsZ. Finally, subdomain 1C, which is in a unique position relative to MreB and actin, is required for FtsA to recruit downstream cell division proteins such as FtsN. Although FtsA is essential for viability in ''E. coli'', it can be deleted in ''B. subtilis''. ''B. subtilis'' cells lacking FtsA divide poorly, but still survive. Another FtsZ-interacting protein, SepF (originally named YlmF), is able to replace FtsA in ''B. subtilis'', suggesting that SepF and FtsA have overlapping functions. An allele of FtsA called FtsA * (R286W) is able to bypass the normal requirement for the ZipA in ''E. coli'' cytokinesis. FtsA * also causes cells to divide at a shorter cell length than normal, suggesting that FtsA may normally receive signals from the septum synthesis machinery to regulate when cytokinesis can proceed. Other FtsA *-like alleles have been found, and they mostly decrease FtsA-FtsA interactions.ウィキペディア（Wikipedia）』 ■ウィキペディアで「FtsA」の詳細全文を読む スポンサード リンク
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