|
GENCODE is a scientific project in genome research and part of the ENCODE (ENCyclopedia Of DNA Elements) scale-up project. The GENCODE consortium was initially formed as part of the pilot phase of the ENCODE project to identify and map all protein-coding genes within the ENCODE regions (approx. 1% of Human genome). Given the initial success of the project, GENCODE now aims to build an “Encyclopedia of genes and genes variants” by identifying all gene features in the human and mouse genome using a combination of computational analysis, manual annotation, and experimental validation, and annotating all evidence-based gene features in the entire human genome at a high accuracy.〔 The result will be a set of annotations including all protein-coding loci with alternatively transcribed variants, non-coding loci with transcript evidence, and pseudogenes. == Current progress == GENCODE is currently progressing towards its goals in Phase 2 of the project, which are: * To continue improving the coverage and accuracy of the GENCODE human gene set by enhancing and extending the annotation of all evidence-based gene features in the human genome at a high accuracy, including protein-coding loci with alternatively splices variants, non-coding loci and pseudogenes. * To create a mouse GENCODE gene set that includes protein-coding regions with associated alternative splice variants, non-coding loci which have transcript evidence, and pseudogenes.〔 The most recent release of the Human geneset annotations is Gencode 20, with a freeze date of April 2014. This release utilises the latest GRCh38 human reference genome assembly, and corresponds to Ensembl release 76. The latest release for the mouse geneset annotations is Gencode M3, also with a freeze date of April 2014.〔 Since September 2009, GENCODE has been the human gene set used by the Ensembl project and each new GENCODE release corresponds to an Ensembl release. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「GENCODE」の詳細全文を読む スポンサード リンク
|