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Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ2, is a protein that in humans is encoded by the ''GRID2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2895 )〕 This protein together with GluD1 belongs to the delta receptor subtype of ionotropic glutamate receptors. They possess 14-24% sequence homology with AMPA, kainate, and NMDA subunits, but, despite their name, do not actually bind glutamate or various other glutamate agonists. delta iGluRs have long been considered orphan receptors as their endogenous ligand was unknown. They are now believed to bind glycine and D-serine but these do not result in channel opening. == Function == GluD2-containing receptors are selectively/predominantly expressed in Purkinje cells in the cerebellum〔 where they play a key role in synaptogenesis, synaptic plasticity, and motor coordination. GluD2 induces synaptogenesis through interaction of its N-terminal domain with Cbln1, which in turn interacts with presynaptic neurexins, forming a bridge across cerebellar synapses.〔 The main functions of GluD2 in synaptic plasticity are carried out by its intracellular C-terminus. This is regulated by D-serine, which binds to the ligand-binding domain and results in changes in the structure of GluD2 without opening the channel.〔 These changes may signal up to the N-terminal domain or down to the C-terminal domain to alter protein-protein interactions. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「GRID2」の詳細全文を読む スポンサード リンク
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