翻訳と辞書 |
GSK1360707F
GSK1360707F is a new and potent selective triple reuptake inhibitor. structurally related to amitifadine and NS-2359 (GSK-372,475). ==Synthesis==
#BOC Protecting group. #Enolization and trapping with triflate group (cf Comins' reagent). #Suzuki reaction #Reduction (only 1 mol eq. LAH because N-BOC can be reduced to N-Me) #Trifluoroacetic acid (TFA) removal of protecting group. #Simmons–Smith reaction cyclopropanation. #Williamson ether synthesis (c.f. NS patents & paxil).
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