翻訳と辞書 Words near each other ・ GT Legends ・ GT Nexus ・ GT Pro Series ・ GT Racer ・ GT Racers ・ GSIS ・ GSIS Museo ng Sining ・ GSIS-Meralco bribery case ・ GSJ ・ GSK ・ GSK 299423 ・ GSK-189,254 ・ GSK-3 ・ GSK-789,472 ・ GSK1360707F ・ GSK2606414 ・ GSK2831781 ・ GSK3A ・ GSK3B ・ GSK716155 ・ GSKB Almaz-Antey ・ GSL ・ GSL Holdings Ltd. ・ GSL-class berthing pontoon ・ GSL-class Ferry ・ GSL-class power barge ・ GSL-class service barge pontoon ・ GSL/GRSE series of Interceptor Boats ・ GSLI ・ GSLIS Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク GSK2606414 ： ウィキペディア英語版 GSK2606414 GSK2606414 is a drug which is the first selective inhibitor discovered for the enzyme protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), which is involved in various processes relating to cancer and neurodegenerative disorders. GSK2606414 was found to be a potent and selective inhibitor of PERK, with good oral bioavailability and blood-brain barrier penetration. PERK mediates the unfolded protein response pathway which is involved in the initiation of protein synthesis, and this pathway has been implicated in the neurotoxicity of various diseases including prion and Alzheimer's diseases. Treatment with GSK2606414 was found to be neuroprotective in mice against damage caused by prions, and prevented the development of cognitive deficits and other clinical manifestations of prion disease. Extension of lifespan in treated mice was, however, not recorded. However, side effects such as weight loss and elevated blood glucose levels were also observed, likely due to unwanted inhibition of PERK in the pancreas gland, where it is involved in regulating insulin production. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「GSK2606414」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.