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|Section2= |Section3= }} Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria ''Streptomyces toyacaensis'', which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor.〔Allan RD, Johnston GAR, Twitchin B. Effects of Gabaculine on uptake, binding and metabolism of GABA. ''Neuroscience Letters''. 1977;4:51-54.〕 Gabaculine is also known as 3-amino-2,3-dihydrobenzoic acid hydrochloride and 5-amino cyclohexa-1,3 dienyl carboxylic acid. Gabaculine increased GABA levels in the brain and had an effect on convulsivity in mice.〔 == Mechanism of Action == Gabaculine includes a comparable structure to GABA and a dihydrobenzene ring. This comparable GABA structure is used in order to be able to take the place of GABA during the first steps of transamination, including transaldimination and 1,3-prototrphic shift to the pyridoxamine imine. Following this, a proton from the dihydrobenzene ring is abstracted by an enzymatic base, thus causing the ring to become aromatic.〔 The aromatic stabilization energy of the aromatic ring is what causes this reaction to be irreversible, thus causing the complex not to react further.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Gabaculine」の詳細全文を読む スポンサード リンク
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