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Galectin-3 is a protein that in humans is encoded by the ''LGALS3'' gene. Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3958 )〕 Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides.〔〔.〕 Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22.〔 Galectin-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space.〔〔〔 == Function == Galectin-3 has an affinity for beta-galactosides and exhibits antimicrobial activity against bacteria and fungi.〔 This protein has been shown to be involved in the following biological processes: cell adhesion, cell activation and chemoattraction, cell growth and differentiation, cell cycle, and apoptosis.〔 Given galectin-3’s broad biological functionality, it has been demonstrated to be involved in cancer, inflammation and fibrosis, heart disease, and stroke.〔〔 Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular remodeling.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Galectin-3」の詳細全文を読む スポンサード リンク
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