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Gelsemine
Gelsemine (C20H22N2O2) is an alkaloid that comes from the flowering plant, ''Gelsemium sempervirens'', and is a highly toxic compound that acts as a paralytic and often results in death. It acts as an agonist for the glycine receptor with a significantly higher binding affinity than glycine. Recent pharmacological research has suggested that this compound can be effective in the treatment of anxiety and other conditions, and is searching for a safe way to utilize these beneficial effects. ==History== While Arthur Conan Doyle is most commonly known as the mastermind behind Sherlock Holmes, he also was a doctor with a similar madness to that of Sherlock’s. Doyle’s first academic publication was concerning the effects of Gelsemium intoxication in humans. After observing the successful treatment of a gelsemium tincture for neuralgia, he became determined to “ascertain how far one might go in taking the drug, and what the primary symptoms of an overdose might be.” To do this, Doyle ingested increasing doses of his prepared tincture every day and published his results in the British Medical Journal. He determined that an adult could safely ingest up to 90 minims of the gelsemium tincture (1 minim = 1/480 fluid ounces).
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