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GeneNetwork
GeneNetwork is a database and open source bioinformatics software resource for systems genetics. This resource is used to study gene regulatory networks that link DNA sequence variants to corresponding differences in gene and protein expression and to differences in traits such as health and disease risk. Data sets in GeneNetwork are typically made up of large collections of genotypes (e.g., SNPs) and phenotypes that are obtained from groups of related individuals, including human families, experimental crosses of strains of mice and rats, and organisms as diverse as Drosophila melanogaster, Arabidopsis thaliana, and barley. The inclusion of genotypes for all individuals makes it practical to carry out web-based gene mapping to discover those regions of the genome that contribute to differences in gene expression, cell function, anatomy, physiology, and behavior among individuals.
==History==
GeneNetwork was created at the University of Tennessee Health Science Center, Memphis USA in 2000-2001 as a web-based extension of the (Portable Dictionary of the Mouse Genome ) and Kenneth F. Manly's (Map Manager ) QT and QTX programs and was initially called WebQTL. Gene mapping data sets were incorporated for several mouse recombinant inbred strains. By early 2003, the first large Affymetrix gene expression data sets (whole mouse brain mRNA and hematopoietic stem cells) were incorporated and the system was renamed. GeneNetwork is now developed by an international group of developers and has mirror and development sites in Europe, Asia, and Australia. Production and test GeneNetwork services are hosted on the Amazon Elastic Compute Cloud.
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