翻訳と辞書 Words near each other ・ Geranyl diphosphate 2-C-methyltransferase ・ Geranyl diphosphate diphosphatase ・ Geranyl pyrophosphate ・ Geranyl-diphosphate diphosphate-lyase ・ Geranyl-diphosphate diphosphohydrolase ・ Geranyl-pyrophosphate—olivetolic acid geranyltransferase ・ Geranylfarnesyl diphosphate synthase ・ Geranylfarnesyl pyrophosphate ・ Geranylgeraniol ・ Geranylgeraniol 18-hydroxylase ・ Geranylgeranyl diphosphate diphosphatase ・ Geranylgeranyl diphosphate reductase ・ Geranylgeranyl pyrophosphate ・ Geranylgeranyl-diphosphate diphosphohydrolase ・ Geranylgeranyl-diphosphate geranylgeranyltransferase ・ Geranylgeranylation ・ Geranylgeranylglycerol-phosphate geranylgeranyltransferase ・ Geranylgeranyltransferase type 1 ・ Geranylhydroquinone 3''-hydroxylase ・ Geranyltranstransferase ・ Gerar ・ Gerar Jarso ・ Gerarai ・ Gerarca ・ Gerarchia ・ Gerarctia ・ Gerard ・ Gerard & Jacques ・ Gerard 't Hooft ・ Gerard (Aboriginal Council) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Geranylgeranylation ： ウィキペディア英語版 Geranylgeranylation Geranylgeranylation is a form of prenylation, which is a post-translational modification of proteins that involves the attachment of one or two 20-carbon lipophilic geranylgeranyl isoprene units from geranylgeranyl diphosphate to one or two cysteine residue(s) at the C-terminus of specific proteins. Prenylation (including geranylgeranylation) is thought to function, at least in part, as a membrane anchor for proteins.〔Jiang, Yu; Proteau, Philip; Poulter, Dale; Ferro-Novick, Susan (September 15, 1995). ("BTS1 Encodes a Geranylgeranyl Diphosphate Synthase in ''Saccharomyces cerevisiae''" ), ''The Journal of Biological Chemistry'', 270, 21793-21799〕 The process of geranylgeranylation can be catalyzed by either geranylgeranyl transferase I (GGTase I) or Rab GGTase (also GGTase II). GGTase I catalyzes the addition of one geranylgeranyl group onto the C-terminal consensus sequence CAAL (somewhat similar to farnesyltransferase reactions), where C=cysteine, A=any aliphatic amino acid, and L=leucine. Rab GGTase adds a total of two geranylgeranyl groups onto two cysteine residues at the C-terminal consensus sequence CXC or XXCC. The source of the geranylgeranyl group is geranylgeranyl diphosphate, which is synthesized by GGPS1 within the isoprenoid biosynthetic pathway. An example of this can be seen in the lipid anchoring of the Rho GTPase family of signaling molecules and the gamma subunit of heterotrimeric G proteins. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Geranylgeranylation」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.