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Gintonin is a glycolipoprotein fraction isolated from ginseng. The non-saponin ingredient was designated as gintonin, where ''gin'' was derived from ginseng, ''ton'' from the tonic effects of ginseng, and ''in'' from protein. The main component of gintonin is a complex of lysophosphatidic acids (LPA) and ginseng proteins such as Ginseng major latex-like protein151 (GLP151) and ginseng ribonuclease-like storage protein. GLP151 is a first plant-derived LPA binding protein as one of Bet v 1 superfamily. GLP151 has a LPA binding domain on H147 and H148 at C-terminal. These two histidine residues bind to phosphate group of LPA and deliver LPA to its cognate receptors to elicit cellular effects such as ()i transient and morphological changes. Lysophospholipid receptors are the high affinity and selective target receptor of gintonin. Gintonin induces ()i transient in animal cells. Gintonin also shows ''in vivo'' anti-Alzheimer's disease through LPA receptor-mediated non-amyloidogenic pathway and boosting of hippocampal cholinergic system 〔 〕 and ''in vivo'' anti-metastatic effect by inhibition of autotaxin activity. ==See also== * Ginseng * Ginsenoside * Lysophosphatidic acid * Lysophospholipid receptor 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Gintonin」の詳細全文を読む スポンサード リンク
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