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Glycopeptide
Glycopeptides are peptides that contain carbohydrate moieties (glycans) covalently attached to the side chains of the amino acid residues that constitute the peptide.
Over the past few decades it has been recognised that glycans on cell surface (attached to membrane proteins or lipids) and those bound to proteins (glycoproteins) play a critical role in biology. For example these constructs have been showed to play important roles in fertilization,〔Talbot, P.; Shur, B. D.; Myles, D. G., Cell adhesion and fertilization: Steps in oocyte transport, sperm-zona pellucida interactions, and sperm-egg fusion. Biology of Reproduction 2003, 68, (1), 1-9.〕 the immune system,〔Rudd, P. M.; Elliott, T.; Cresswell, P.; Wilson, I. A.; Dwek, R. A., Glycosylation and the immune system. Science 2001, 291, (5512), 2370-2376.〕 brain development,〔Varki, A., Biological Roles of Oligosaccharides - All of the Theories Are Correct. Glycobiology 1993, 3, (2), 97-130.〕 the endocrine system〔 and inflammation.〔〔Bertozzi, C. R.; Kiessling, L. L., Chemical glycobiology. Science 2001, 291, (5512), 2357-2364.〕〔
The synthesis of glycopeptides provides biological probes for researchers to elucidate glycan function in nature and products that have useful therapeutic and biotechnological applications.
==Glycopeptide Linkage Variety==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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