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The concept of grading of the tumors of the central nervous system, agreeing for such the regulation of the "progressiveness" of these neoplasias (from benign and localized tumors to malignant and infiltrating tumors), dates back to 1926 and was introduced by P. Bailey and H. Cushing,〔 Bailey P, Cushing H (1926). ''A classification of the tumors of the glioma group on a histogenic basis with a correlated study of prognosis.'' J B Lippincott Co. Philadelphia.〕 in the elaboration of what turned out the first systematic classification of gliomas.〔 Tonn J-C, Westphal M, Rutka JT, Grossman SA (2006). ''Neuro-Oncology of CNS Tumors'' Springer Science & Business, ISBN 3-540-25833-7.〕 In the following, the grading systems present in the current literature are introduced. Then, thru a table, the more relevant are compared. ==ICD-O scale== The first edition of the International Classification of Diseases (ICD) dates back to 1893, the current review (ICD-10) dates 1994. In 1976 the World Health Organization (WHO) publishes the first edition of the International Classification of Diseases for Oncology (ICD-O), now at the third edition (ICD-O-3, 2000). In this last edition, the Arabic numeral after the character "/" indicates the "behavior" of the neoplasia, with the following meaning:〔Vicari P (2007). ''(Principi di codifica delle neoplasie. )'' Reggio Emilia dicembre 2007. Accessed on 2009-08-12.〕 */0 benign neoplasia */1 uncertain neoplasia (benign or malignant) */2 neoplasia ''in situ'' */3 primary infiltrative malignant neoplasia */6 secondary malignant neoplasia */9 malignant neoplasia, uncertain if primitive or secondary For the concepts of ''benign'' and ''malignant'' neoplasia see Tumor and Cancer. For ''primary'' and ''secondary'' neoplasias see Metastasis. A brain tumor composed of benign cells, but located in a vital area (as the brain is), can be considered to be life-threatening — although the tumor and its cells would not be classified as malignant. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Grading of the tumors of the central nervous system」の詳細全文を読む スポンサード リンク
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