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Grammotoxin
Grammotoxin is a toxin in the venom of the tarantula ''Grammostola spatulata''. It is a protein toxin that inhibits P-, Q- and N-type voltage-gated calcium channels (Ca 2+ channels) in neurons. Grammotoxin is also known as omega-grammotoxin SIA. == Chemistry ==
Grammotoxin is a 36 Amino Acid protein toxin, which has the following sequence: Asp-Cys-Val-Arg-Phe-Trp-Gly-Lys-Cys-Ser-Gln-Thr-Ser-Asp-Cys-Cys-Pro-His-Leu-Ala-Cys-Lys-Ser-Lys-Trp-Pro-Arg-Asn-Ile-Cys-Val-Trp-Asp-Gly-Ser-Val (1) It forms an inhibitor cystine knot motif, common in spider toxins.〔 Its chemical formula is: C177H268N52O50S6〔(ω-Grammotoxin SIA from Grammostola spatulata venom, ≥98% (HPLC) )〕 Grammotoxin can be purified from ''Grammostola spatulata'' venom by reverse phase high performance liquid chromatography.
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